Principal Investigator
Dr. Ye-Guang Chen
Professor
Academician of the CAS
Principal Investigator
Dr. Ye-Guang Chen
Professor
Academician of the CAS
Research
Our group has long been dedicated to interdisciplinary investigations at the interface of cellular signaling and organoid technology. By integrating approaches from cell biology, molecular biology, bioinformatics, and genetics, and combining organoid systems with animal models and multi-omics analyses, we conduct systematic research centered on the following core areas:
Systematically investigate the regulatory mechanisms governing adult stem cell self-renewal and lineage-specific differentiation,
and identify key molecular targets that mediate stem cell-driven tissue homeostasis and injury repair.
Develop and optimize novel culture systems for multiple organoid types, including intestinal, gastric, pulmonary, hepatic, renal,
and pancreatic organoids, to enhance long-term stability and functional integrity.
Publications
Li SQ*, Zhang Z*, Lv QK*, Cao YF, Song CH, Liang JH, Qi YF, Duan ZY, Wang
YL#, Chen YG#.
（2026）PLAU⁺ fibroblasts
drive lung adenocarcinoma chemoresistance through the CXCL5-calmegin axis, Cancer Research, In press.
Zhang MX*, Zang ZY*, Song WL*,
Lyu JY, Wang X, Chen YG#.
（2026） The
p53-YSC-YAP axis mediates enterocyte dedifferentiation during colonic
regeneration after irradiation, Cell Discovery, In press.
Xiao CY*, Guo YQ*, Liu Y, Wang T, Liu
HT, Wang YL, Chen XY, Zhang MX, Tan RH, Fang Z, Liu HD, Yao ZY, Lei X, Qin JH#, Chen YG#.
（2026）Evaluation of
Anti-Tumor Drugs by Simulating Physiological Absorption and Metabolism with A
Multi-Organoid System, Cell Systems, 101734.
molcell@tsinghua.edu.cn
010-62784794