Principal Investigator
Dr. Ye-Guang Chen
Professor
Academician of the CAS
Principal Investigator
Dr. Ye-Guang Chen
Professor
Academician of the CAS
Research
Our group has long been dedicated to interdisciplinary investigations at the interface of cellular signaling and organoid technology. By integrating approaches from cell biology, molecular biology, bioinformatics, and genetics, and combining organoid systems with animal models and multi-omics analyses, we conduct systematic research centered on the following core areas:
Systematically investigate the regulatory mechanisms governing adult stem cell self-renewal and lineage-specific differentiation,
and identify key molecular targets that mediate stem cell-driven tissue homeostasis and injury repair.
Develop and optimize novel culture systems for multiple organoid types, including intestinal, gastric, pulmonary, hepatic, renal,
and pancreatic organoids, to enhance long-term stability and functional integrity.
Publications
Shen YH, Li CL, Zhang HQ,
Liu HD, Zhao LZ#, Chen YG#.
（2026）A progenitor cell
population contributes to prenatal injury repair and neonatal antimicrobial
defense in the small intestine, Cell Reports, 45(6):117503.
Zhao LZ, Xie YC, Song WL,
Shen YH, Liu HD, Luo SW, Chen YG#.
（2026）Lgr5⁺ cells regulate
small intestinal morphogenesis before villification, Cell Regeneration, 15(1):10.
Yang LY*, Wang X*, Wei XY*,
Yu P, Wang SX, Lin YF, Yang Y, Jiang T, Liu Y, Qiao ZP, Zhang JX, Yu SC, Chen YG#, Chan YS#. （2026）Oral Delivery of
R-spondin1-Loaded Small Extracellular Vesicles Activates WNT Signaling Pathway to
Accelerate Intestinal Injury Repair and Reverse Aging, Journal of Extracellular Vesicles,
15(1):e70226.
molcell@tsinghua.edu.cn
010-62784794