Principal Investigator
Dr. Ye-Guang Chen
Professor
Academician of the CAS
Principal Investigator
Dr. Ye-Guang Chen
Professor
Academician of the CAS
Research
Our group has long been dedicated to interdisciplinary investigations at the interface of cellular signaling and organoid technology. By integrating approaches from cell biology, molecular biology, bioinformatics, and genetics, and combining organoid systems with animal models and multi-omics analyses, we conduct systematic research centered on the following core areas:
Systematically investigate the regulatory mechanisms governing adult stem cell self-renewal and lineage-specific differentiation,
and identify key molecular targets that mediate stem cell-driven tissue homeostasis and injury repair.
Develop and optimize novel culture systems for multiple organoid types, including intestinal, gastric, pulmonary, hepatic, renal,
and pancreatic organoids, to enhance long-term stability and functional integrity.
Publications
Yang LY*, Wang X*, Wei XY*,
Yu P, Wang SX, Lin YF, Yang Y, Jiang T, Liu Y, Qiao ZP, Zhang JX, Yu SC, Chen YG#, Chan YS#. （2026）Oral Delivery of
R-spondin1-Loaded Small Extracellular Vesicles Activates WNT Signaling Pathway to
Accelerate Intestinal Injury Repair and Reverse Aging, Journal of Extracellular Vesicles,
15(1):e70226.
Zou T, Zhang S, Liu M, Chen
Q, Wang S, Niu L, Chen YG, Zhang T,
Zuo W#.（2026）Control of airway
basal stem cell-mediated lung repair by TGF-β signaling, Science
Advances, 12(2):eadz1519.
Xiao YH*, Yu SC*, Zhang MX,
Zhong NS, Hua S, Fang Z, Zhang Z, Liu HD, Tan RH, Liu Y, Chen YG#. （2025） Crotonate enhances intestinal
regeneration after injury via HBO1-mediated H3K14 crotonylation, Nature
Communications, 16(1):8800.
molcell@tsinghua.edu.cn
010-62784794