# Corresponding


Li YZ*, Liu Y*, Y. Jeffrey Chiang, Huang F, Li YH, Li XT,Ning YH, Zhang WH, Deng HT,Chen YG#.  2019  DNA Damage Activates TGF-b Signaling via ATM-c-Cbl-Mediated Stabilization of the Type II Receptor TbRII.  Cell Reports, In press.


Shi QN, Chen YG#.  2019   The functional switch of TGF-β signaling in breast cancer.  Oncotarget, 10(17):1604-1605. (Review) .


Shi QN, Chen YG#.  2019   ALK-mediated Tyr95 phosphorylation of Smad4 impairs its transcription activity and the tumor suppressive activity of TGF-β.  Science China Life Science, 62(3):431-432. (Review) .




Huang F*, Shi QN*, Li Y, Xu L, Xu C, Chen F, Wang H, Liao H, Chang Z, Liu F, Zhang X, Feng X, Han J, Luo S, Chen YG#.  2018   HER2/EGFR-AKT signaling switches TGF-β from inhibiting cell proliferation to promoting cell migration in  breast  cancer.  Cancer Research. 78(21):6073-6085.


Liu Y*, Qi Z*, Li X, Du Y,  Chen YG#.  2018   Monolayer culture of intestinal epithelium sustains Lgr5+ intestinal stem cellsCell Discovery.  4:32.


Ye P, Chiang YJ, Qi Z, Li Y, Wang S, Liu Y, Li X, Chen YG#. 2018  Tankyrases maintain homeostasis of intestinal epithelium by preventing cell death. PLoS Genetics. 14(9):e1007697.


Li YH*, Liu Y*, Liu BF, Wang JL, Wei ST, Qi Z, Wang S, Fu W, Chen YG#,  2018  A growth factor-free culture system underscores the coordination between Wnt and BMP signaling in Lgr5+ intestinal stem cell maintenanceCell Discovery,  4:49.


Xu X, Wang L, Liu B, Xie W, Chen YG#. 2018 Activin/Smad2 and Wnt/β-catenin upregulate HAS2 and ALDH3A2 to facilitate mesendoderm differentiation of human ESCsJournal of Biological Chemistry, 293(48):18444-18453.


Yan X#*, Wu J*, Jiang Q, Cheng H, Han J, Chen YG#.  2018  CXXC5 suppresses hepatocellular carcinoma by promoting TGF-β-induced cell cycle arrest and apoptosisJournal of Molecular Cell Biology. 10(1):48-59.


Liu Y, Chen YG#. 2018  2D- and 3D-Based Intestinal Stem Cell Cultures for Personalized Medicine. Cells, 7(12). pii: E225. (Review) 


Wang S, Chen YG#. 2018 BMP signaling in homeostasis, transformation and inflammatory response of intestinal epithelium. Science China Life Science, 61(7):800-807. (Review) 


Yan X#, Xiong X, Chen YG#.  2018  Feedback regulation of TGF-β signaling.  Acta Biochimica et Biophysica Sinica , 50(1):37-50. (Review) 




Qi Z*, Li Y*, Zhao B, Xu C, Liu Y, Li H, Zhang B, Wang X, Yang X, Xie W, Li B, Han J, Chen YG#. 2017  BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes.  Nature Communications.  8:13824.


Wu Y*, Li Y*, Li X, Zou Y, Liao H, Liu L, Chen YG#, Bierer D#, Hu H#.  2017  A novel peptide stapling strategy enables the retention of ring-closing amino acid side chains for the Wnt/b-catenin signalling pathwayChemical Science, 8(11):7368-7373.


Wang L*, Xu X*, Cao Y, Li Z, Cheng H, Zhu G, Duan F, Na J, Han JD, Chen YG#. 2017  Activin/Smad2-induced H3K27me3 reduction is crucial to initiate mesendoderm differentiation of human embryonic stem cells.   Journal of Biological Chemistry,  292(4):1339-1350.


Hata A#Chen YG#. 2017.  TGF-β Signaling from Receptors to Smads.Cold Spring Harbor Perspectives in Biology, 8(9). (Review)


Shi QN, Chen YG#. 2017. Interplay between TGF-β signaling and receptor tyrosine kinases in tumor developmentSCIENCE CHINA Life Sciences, 60(10):1133-1141. (Review)


徐玄昊,陈晔光#.  2017.  胚胎干细胞向中内胚层分化的调控机制生命科学, 27(10):1016-1024. (Review) 


Yu Y, Gu S, Li W, Sun C, Chen F, Xiao M, Wang L, Xu D, Li Y, Ding C, Xia Z, Li Y, Ye S, Xu P, Zhao B, Qin J, Chen YG, Lin X, Feng XH#.  2017  Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-β signaling. Proc Natl Acad Sci. USA. 114(38):10113-10118. 


Wang J, Qi Z, Li Y, Zhao H, Chen YG, Fu W#.  2017  TGFβ induced factor homeobox 1 promotes colorectal cancer development through activating Wnt/β-catenin signaling.  Oncotarget, 8(41):70214-70225


Lin H, Ying Y, Wang Y, Wang G, Jiang S, Huang D, Luo L, Chen YG, Gerstenfeld C, Luo ZJ#.  2017  AMPK Downregulates ALK2 via Increasing the Interaction between Smurf1 and Smad6, leading to inhibition of in vitro Osteogenic Differentiation.  BBA Molecular Cell Research. 1864(12):2369-2377.




Cheng MZ*, Xue H*, Cao WP, Li WX, Chen H, Liu BF, Ma BY, Yan XH, Chen YG#.  2016   RACK1 promotes Dishevelled degradation via autophagy and antagonizes Wnt signaling.  Journal of Biological Chemistry,  291(24):12871-9.


Yan XH#, Liao HW, Cheng MZ, Shi X, Lin X, Feng XH, Chen YG#.  2016   Smad7 Interacts with R-Smads to Inhibito TGF-beta/Smad Signaling Journal of Biological Chemistry,  291(1):382-92.


Chen YG#, Ezhkova E#, Ostankovitch M#. 2016  Molecular mechanisms regulating stem cells fate.Journal of Molecular Biology, 428:1407-1408. (Editorial).


Wang L, Chen YG#.  2016  Signaling Control of Differentiation of Embryonic Stem Cells toward MesendodermJournal of Molecular Biology, 428(7):1409-22. (Review)


Yan X, Chen YG#. 2016  Posttranslational Modifications of TGF-β Receptors. Methods in Molecular Biology, 1344:49-61.



Zhao B*, Qi Z*, Li YH*, Wang C, Fu W, Chen YG#. 2015   The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells.  Nature Communications.  6:7166.


Zhu GY, Fei T, Li ZW, Yan XH, Chen YG#.  2015   Activin regulates self-renewal and differentiation of trophoblast stem cells by down-regulating the X-chromosome gene BcorJournal of Biological Chemistry 290(36):22019-29.


He K, Yan XH, Li N, Dang S, Xu L, Zhao B, Li Z, Lv Z, Fang XH#, Zhang Y#, Chen YG#. 2015   Internalization of the TGF-β type I receptor into caveolin-1 and EEA1 double-positive early endosomesCell Research.  25:738-752.


Ma BY*, Liu BF*, Cao WP, Gao C, Qi Z, Ning YH, and Chen YG#.  2015  The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced AutophagyJournal of Biological Chemistry,  290(19):12346-12354.


Du J*, Hong S*, Dong L, Cheng B, Lin L, Zhao B, Chen YG#, Chen X#.  2015  Dynamic Sialylation in Transforming Growth Factor-β-Induced Epithelial to Mesenchymal Transition.  Journal of Biological Chemistry, 290(19):12000-12013.


Huang YS, Wang P, Chen H, Ding Y, Chen YG#.  2015  Myc-interacting zinc-finger protein 1 positively regulates Wnt signalling by protecting Dishevelled from Dapper1-mediated degradation.  Biochemical Journal, 466(499–509).


Qi Z, Chen YG#. 2015  Regulation of intestinal stem cell fate specificationScience China Life Sciences. 58(6)570-578. (Review)


Lin L, Liu L, Zhao B, Xie R, Lin W, Li H, Li Y, Shi M, Chen YG, Springer TA, Chen X.  2015  Carbon nanotube-assisted optical activation of TGF-β signalling by near-infrared light. Nature Nanotechnology,  10:465-471.


Sun G, Hu Z, Min Z, Yan X, Guan Z, Su H, Fu Y, Ma X, Chen YG, Tao Q, Wu W. 2015  Small C-terminal Domain Phosphatase 3 Dephosphorylates the Linker Sites of Receptor-regulated Smads (R-Smads) to Ensure Transforming Growth Factor (TGF)-mediated Germ Layer Induction in Xenopus Embryos.  Journal of Biological Chemistry, 290(28):17239-17249. 




Ma BY*, Cao WP*, Li WX, Gao C, Qi Z, Zhao Y, Du J,  Xue H, Peng JY, Wen J,  Chen H, Ning YH,  Huang L, Zhang H, Gao X, Yu L, Chen YG#. 2014   Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation.  Cell Research,  24(8):912-24. 

Zhang Y*, Ding Y*Chen YG#, Tao QH#. 2014  NEDD4L regulates convergent extension movements in Xenopus embryos via Disheveled-mediated non-canonical Wnt signaling.  Developmental Biology, 392:15-25.

Zuo W, Chen YG#   2014  TGF-β signaling in hematopoietic stem cells and leukemiaCancer Hallmarks, 1:91-97. (Review)

Zhao B, Chen YG#  2014  Regulation of TGF-β signaling.  Scientifica, 2014:874065(Review)

Yan XH, Pan J, Xiong W, Cheng MZ, Sun Y, Zhang SP, Chen YG   2014   Yin Yang 1 (YY1) synergizes with Smad7 to inhibit TGF-β signaling in the nucleusScience China Life Sciences, 57: 128-136.

Xu PF*, Zhu GY*, Wang Y, Sun J, Liu X, Chen YG, Meng AM#.  2014  Maternal Eomesodermin regulates zygotic nodal gene expression for mesendoderm induction in zebrafish embryos.  Journal of Molecular Cell Biology, 6(4), 272–285.

Li Y, Wu H, Wu W, Zhuo W, Liu WX, Zhang YX, Cheng MZ, Chen YG, Gao N, Yu HT, Wang LF, Li W, Yang MJ.  2014  Structural insights into the TRIM family of ubiquitin E3 ligases.  Cell Research, 24:762-765.

Ding Y, Su S, Tang W, Zhang X, Chen S, Zhu G, Liang J, Wei W, Guo Y, Liu L, Chen YG, Wu W  2014  The S-G2 phase enriched β-catenin/TCF complex ensures cell survival and cell cycle progression. Journal of Cell Science, 127(22):4833-45.

Luo W, Xia T, Xu L, Chen YG, Fang X.  2014  Visualization of the post-Golgi vesicle-mediated transportation of TGF-β receptor II by quasi-TIRFMJournal of Biophotonics7(10):788-798.



Zuo W*, Huang F*, Chiang YJ, Li M, Du J, Ding Y, Zhang T, Lee HW, Jeong LS, Chen Y, Deng H, Feng XH, Luo S, Gao C, Chen YG#  2013  c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor.  Molecular Cell, 49(3):499-510.

Cui HK*, Zhao B*, Li YH, Guo Y, Hu H, Liu L#Chen YG#  2013  Design of stapled α-helical peptides to specifically activate Wnt/β-catenin signalingCell Research, 23(4):581-584.

Tao R, Xue H, Zhang JP, Liu J, Deng H, Chen YG#  2013  The deacetylase Rpd3 facilitates checkpoint adaptation by preventing Rad53 over-activationMolecular and Cellular Biology, 43:4212-4224. (Highlighted in Spotlight by the Editor)

Xue H, Xiao Z, Zhang J, Wen J, Wang Y, Chang Z, Zhao J, Gao X, Du J, Chen YG#  2013  Disruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/β-catenin signaling.  Journal of Biological Chemistry, 288(21):15006-15014.

Ding Y*, Zhang Y*, Xu C, Tao QH#Chen YG#  2013  HECT Domain-containing E3 ubiquitin ligase NEDD4L negatively regulates Wnt signaling by targeting Dishevelled for proteasomal degradation Journal of Biological Chemistry, 288:8289-8298.

Zhang JP, Fei T, Li ZW, Zhu GY, Wang L, Chen YG#  2013  BMP induces cochlin expression to facilitate self-renewal and suppress neural differentiation of mouse embryonic stem cellsJournal of Biological Chemistry, 288:8053-8060.

Li ZW, Chen YG#  2013  Functions of BMP signaling in embryonic stem cell fate determinationExperimental Cell Research, 319:113-119. (Review) 

​Conidi A, van den Berghe V, Leslie K, Stryjewska A, Xue H, Chen YG, Seuntjens E, Huylebroeck D.  2013  Four amino acids within a tandem QxVx 1 repeat in a predicted extended α-2 helix of the Smad-binding domain of Sip1 are necessary for binding to activated Smad proteins. PLoS One, 8(10): e76733. 

Liu X, Xiong C, Jia S, Zhang Y, Chen YG, Wang Q, Meng A#.  2013  Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm induction and patterning by directly phosphorylating Smad2 linkerNature Communications, 4:1-11.

Zhao M, Yang X, Fu Y, Wang H, Ning Y, Yan J, Chen YG, Wang G#  2013  Mediator MED15 modulates TGFβ/Smad signaling and breast cancer cell metastasis. Journal of Molecular Cell Biology, 5(1):57-60.

Margariti A, Li H, Chen T, Martin D, Vizcay-Barrena G, Alam S, Karamariti E, Xiao Q, Zampetaki A, Zhang Z, Wang W, Jiang Z, Gao C, Ma B, Chen YG, Cockerill GW, Hu Y, Xu Q, Zeng L#  2013  XBP1 mRNA splicing triggers an autophagic response In endothelial cells through Beclin-1 transcriptional activationJournal of Biological Chemistry, 288(2):859-872.

Yu J, He X, Chen YG, Hao Y, Yang S, Wang L, Pan L, Tang H#  2013 Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteinsJournal of Biological Chemistry, 288(1):79-88.



Li ZW*, Fei T*, Zhang JP, Zhu GY, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG#  2012  BMP4 signaling acts via Dual Specificity Phosphatase 9 to control ERK activity in mouse embryonic stem cellsCell Stem Cell, 10:171-182.

Zhao B, Wang Q, Du J, Luo S, Xia J, Chen YG#  2012  PICK1 promotes caveolin-dependent degradation of TGF-β type I receptorCell Research, 22:1467-1478.

Shi Y*, Ding Y*, Lei YP, Yang XY, Xie GM, Wen J, Cai CQ, Li H, Chen Y, Zhang T, Wu BL, Jin L, Chen YG#, Wang HY#  2012  Identification of novel rare mutations of DACT1 in human neural tube defectsHuman Mutation, 33:1450-1455.

Zhang H, Zhang YW, Chen Y, Huang X, Zhou F, Wang W, Xian B, Zhang X, Masliah E, Chen Q, Han JD, Bu G, Reed J, Liao FF, Chen YG#, Xu H#  2012  Appoptosin is a novel proapoptotic protein and mediates cell death in neurodegenerationJournal of Neuroscience, 32:155565-155576. 

Yan XH, Zhang J, Sun Q, Tuazon PT, Wu X, Traugh JA, Chen YG#  2012  p21-activated kinase 2 (PAK2) inhibits TGF-β signaling in Madine-Darby canine kidney (MDCK) epithelial cells by interfering with the receptor-Smad interactionJournal of Biological Chemistry, 287: 13705-13712.

Chen YG#, Li ZW, Wang XF#  2012  Where PI3K/Akt meets Smads: The crosstalk determines human embryonic stem cell fate.Cell Stem Cell, 10:231-232. (Preview)  

Li ZW, Chen YG#  2012  Fine-tune of intrinsic ERK activity by extrinsic BMP signaling in mouse embryonic stem cellsProtein Cell, 3:401-404. (Perspective)

Huang F, Chen YG#  2012  Regulation of TGF-β receptor activity. Cell & Bioscience 2012, 2:9 (doi:10.1186/2045-3701-2-9) (Review)

Kua HY, Liu H, Leong WF, Li L, Jia D, Ma G, Hu Y, Wang X, Chau JFL, Chen YG, Mishina Y, Boast S, Yeh J, Xia L, Chen GQ, He L, Goff SP, Li B#  2012  c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expressionNature Cell Biology, 14(7):727-737.

Xiang H, Feng Y, Wang J, Liu B, Chen YG, Liu L, Deng X, Yang M#  2012  Crystal structures reveal the multi-ligand binding mechanism of Staphylococcus aureus ClfBPLoS Pathogens, 8:e1002751.

Klionsky DJ,……..Chen YG…….. 2012  Guidelines for the use and interpretation of assays for monitoring autophagyAutophagy, 8(4):445-544.

Chau JFL, Jia D, Wang Z, Liu Z, Hu Y, Zhang X, Jia H, Lai KP, Leong WF, Au BJ, Mishina Y, Chen YG, Biondi C, Robertson E, Xie D, Liu H, He L, Wang X, Yu Q, Li B#  2012  A crucial role for bone morphogenetic protein-Smad1 signalling in the DNA damage responseNature Communications, 3:836.



Tao R, Chen H, Gao C, Xue P, Yang F, Han JD, Zhou B, Chen YG#   2011  Xbp1-mediated histone H4 deacetylation contributes to DNA double-strand break repair in yeast. Cell Research, 21:1619-1633.

Yan XH, Zhang Y, Pan L, Wang P, Xue H, Zhang L, Gao X, Zhao X, Ning Y, Chen YG#   2011  TSC-22 promotes TGF-β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.  Molecular and Cellular Biology, 31:3700-3709.

Geng Y, Dong Y, Yu M, Zhang L, Yan X, Sun J, Qiao L, Geng H, Nakajima M, Furuichi T, Ikegawa S, Gao X, Chen YG#, Jiang D#, Ning W#  2011  Fstl1 is a BMP4 signaling antagonist in controlling mouse lung development. Proc Natl Acad Sci. USA, 108(17):7058-63. 

Chen H, Liu L, Ma B, Ma TM, Hou JJ, Xie GM, Wu W, Yang FQ, Chen YG#  2011  Protein kinase A-mediated 14-3-3 association impedes human Dapper1 to promote Dishevelled degradationJournal of Biological Chemistry, 286:14870-14880.

Yan XH, Chen YG#  2011  Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signaling. Biochemical Journal, 434:1-10. (Review)

Gao C, Chen YG#  2011  Selective removal of Dishevelled by autophagy: a role of p62Autophagy, 7:20-21. (Punctum)

Xie Z, Chen Y, Li Z, Bai G, Zhu Y, Yan R, Tan F, Chen YG, Guillemot F, Li L, Jing N#.  2011  Smad6 promotes neuronal differentiation in the intermediate zone of the dorsal neural tube by inhibition of the Wnt/β-catenin pathwayProc Natl Acad Sci. USA, 108:12119-12124.



Gao C*, Cao WP*, Bao L, Zuo W, Xie G, Cai T, Fu W, Zhang J, Wu W, Zhang X, Chen YG#  2010  Autophagy negatively regulates Wnt signaling by promoting Dishevelled degradationNature Cell Biology, 12:781-790.

Fei T, Zhu SS, Xia K, Zhang JP, Li ZW, Han JD#Chen YG#  2010  Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells. Cell Research, 20:1306-1318. 

Fei T, Xia K, Li ZW, Zhou B, Zhu SS, Chen H, Zhang JP, Chen Z, Xiao H, Han JD#Chen YG#  2010  Genome-wide mapping of Smad target genes reveals the role of BMP signaling in embryonic stem cell fate determinationGenome Research, 20:36-44.

Zhang W, Yuan J, Yang Y, Xu L, Wang Q, Zuo W, Fang XH#Chen YG#   2010  Monomeric type I and type III transforming growth factor-β receptors and their dimerization. Cell Research, 20:1216-1223. 

Wen J, Chiang YJ, Gao C, Xue H, Xu J, Ning YH, Hodes RJ, Gao X, Chen YG#.  2010  Loss of Dact1 disrupts PCP signaling by altering Dishevelled activity and leads to posterior malformation in mice.  Journal of Biological Chemistry, 285:11023-11030.

Fei T, Chen YG#   2010  Regulation of embryonic stem cell self-renewal and differentiation by TGF-β family signaling. Science China Life Science, 53: 497-503. (Review)

Gao C, Chen YG#  2010  Dishevelled: the hub of Wnt signaling. Cellular Signaling, 22:717-727. (Review)

Sun Y, Fei T, Yang T, Zhang F, Chen YG, Li H, Xu Z#  2010  The suppression of CRMP2 expression by BMP-Smad gradient signaling controls multiple stages of neuronal developmentJournal of Biological Chemistry, 285(50):39039-50.

Sheng N, Xie Z, Wang C, Zhang K, Zhu Q, Guillemot F, Chen YG, Lin A, Jing N#  2010  Retinoic acid regulates bone morphorgenic protein signal duration by promoting the degradation of phosphorylated Smad1Proceedings of The National Academy of Sciences of The USA, 107:18886-91.

Wang Y, Fu Y, Gao L, Zhu G, Liang J, Gao C, Huang B, Fenger U, Niehrs C, Chen YG, Wu W#,  2010  Xenopus Skip modulates Wnt/β-catenin signaling and functions in neural crest inductionJournal of Biological Chemistry, 285:10890-10901.

Yu J, Pan L, Qin X, Chen H, Xu Y, Chen YG, Tang H#  2010  MTMR4 Attenuates TGF-β Signaling by Dephosphorylating R-Smads in EndosomesJournal of Biological Chemistry, 285:8454-8462.



Zhang W, Jiang Y, Wang Q, Ma X, Xiao Z, Zuo W, Fang XH#Chen YG#  2009  Single molecule imaging reveals transforming growth factor-β-induced type II receptor dimerization.Proc Natl Acad Sci. USA, 106:15679-15683.

Zuo W, Chen YG#  2009  Specific activation of MAPK by TGF-β receptors in lipid rafts is required for epithelial cell plasticityMolecular Biology of the Cell, 20:1020-1029. 

Yan XH, Lin L, Chen F, Zhao XG, Chen H, Ning YH, Chen YG#  2009  Human BAMBI cooperates with Smad7 to inhibit TGF-β signalingJournal of Biological Chemistry, 284:30097-30104.

严晓华,章隽宇,陈晔光# 2009 抑制性Smad蛋白对TGF-β超家族信号转导的调控及其生理意义细胞生物学杂志,31(2):135-144. (综述)

Chen YG#, Wang, XF#  2009  Finale: the last minutes of Smads.Cell, 139:658-670. (Preview)  

Chen YG, Wang XF  2009  A special issue on TGF-β signalingCell Research, 19:1-2. (Editorial)

Chen YG#  2009  Endocytic regulation of TGF-β signaling. Cell Research, 19:58-70. (Review)

Yan XH, Liu ZY, Chen YG#  2009  Regulation of TGF-β signaling by Smad7. Acta Biochimica et Biophysica Sinica , 41:263-272. (Review) 



Wang Q, Huang Z, Xue H, Jin C, Ju XL, Han JD, Chen YG#  2008  MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood, 111:588-595.

Gao X, Wen J, Zhang L, Li X, Ning Y, Meng A, Chen YG#.  2008  Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus. Journal of Biological Chemistry, 283:35679-35688.

Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG#  2008  The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/β-catenin signaling. Journal of Biological Chemistry, 283:33053-33058.

Zhao XG, Nicholls JM, Chen YG#  2008  SARS-CoV nucleocapsid protein interacts with Smad3 and modulates TGF-β signalingJournal of Biological Chemistry, 283:3272-3280.

Shi X, Chen F, Yu J, Xu Y, Zhang S, Chen YG, Fang X  2008  Study of interaction between Smad7 and DNA by single-molecule force spectroscopyBiochemical and Biophysical Research Communications, 377:1284-1287.



Ma J, Wang Q, Fei T, Han JD, Chen YG#  2007  MCP-1 mediates TGF-β-induced angiogenesis by stimulating vascular smooth muscle cell migrationBlood, 109:987-994.(Commented on Blood, 109:849)

Zhang SP, Fei T, Zhang L, Zhang R, Chen F, Ning Y, Han Y, Feng XH, Meng A, Chen YG#  2007  Smad7 antagonizes TGF-β signaling in the nucleus by interfering with functional Smad-DNA complex formation Molecular and Cellular Biology, 27:4488-4499.

Huang W, Chang HY, Fei T, Wu H, Chen YG#  2007  GSK3β mediates suppression of cyclin D2 expression by tumor suppressor PTENOncogene, 26:2471-2482.

Chen YG#, Wang Z, Ma J, Zhang L, Lu Z  2007  Endofin, a FYVE domain protein, interacts with Smad4 and facilitates TGF-β signaling. Journal of Biological Chemistry, 282:9688-9695.

Su Y, Zhang L, Gao X, Meng FW, Wen J, Zhou H, Meng AM#Chen YG#  2007  The evolutionally conserved activity of Dapper2 in antagonizing TGF-β signalingFASEB Journal, 21:682-690.

Ma X, Wang Q, Jiang Y, Xiao Z, Fang X#Chen YG#  2007  Lateral diffusion of TGF-β type I receptor studied by single-molecule imaging Biochemical and Biophysical Research Communications, 356:67-71.

Diao LR, Chen YG#   2007  PTEN, a general negative regulator of cyclin D expressionCell Research, 17:291-292. (Perspective)

高霞,陈旭煌,陈晔光#  2007  Dapper蛋白在胚胎发育和信号调控中的作用生命科学, 19:471-476. (综述)

Yu J, Wang Q, Shi X, Ma X, Yang H, Chen YG, Fang X  2007  Single-molecule force spectroscopy study of interaction between transforming growth factor β and its receptor in living cells.  Journal of Physical Chemistry B, 111:13619-13625.

Lin X, Chen YG, Meng A, Feng XH  2007  Termination of TGF-β Superfamily Signaling Through SMAD Dephosphorylation-A Functional Genomic View.  Journal of Genetics and Genomics, 34(1): 1-9.



Gu Y, Jin P, Zhang L, Zhao XG, Gao X, Ning YH, Meng A, Chen YG#  2006  Functional analysis of mutations in the kinase domain of the TGF-β receptor ALK1 reveals different mechanisms for induction of hereditary hemorrhagic telangiectasiaBlood, 107:1951-1954.

Zhang L, Gao X, Wen J, Ning YH, Chen YG#  2006  Dapper 1 antagonizes Wnt signaling by promoting Dishevelled degradation.  Journal of Biological Chemistry, 281:8607–8612.

Wu XP, Ma J, Han JD, Wang N, Chen YG#  2006  Distinct regulation of gene expression in human endothelial cells by TGF-β and its receptors.  Microvascular Research, 71:12-19.

Chen YG, Wang Q, Lin SL, Chang CD, Chung J, Ying SY  2006  Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis.  Experimental Biology and Medicine (Maywood), 231(5):534-44. (Review)

Xia K, Xue H, Dong D, Zhu S, Wang J, Zhang Q, Hou L, Chen H, Tao R, Huang Z, Fu Z, Chen YG, Han JD  2006  Identification of the Proliferation/Differentiation Switch in the Cellular Network of Multicellular Organisms PLoS Computational Biology, 2:1482-1497.

Xiong B, Rui Y, Zhang M, Shi K, Jia S, Tian T, Yin K, Huang H, Lin S, Zhao X, Chen Y, Chen YG, Lin SC, Meng A  2006  Tob1 Controls Dorsal Development of Zebrafish Embryos by Antagonizing Maternal β-Catenin Transcriptional Activity  Developmental Cell, 11:225-238.

Wang C, Xia C, Bian W, Liu L, Lin W, Chen YG, Ang SL, Jing N  2006  Cell Aggregation-induced FGF8 Elevation Is Essential for P19 Cell Neural Differentiation.  Molecular Biology of Cell,  17:3075-3084.

Sun Z, Jin P, Tian T, Gu Y, Chen YG, Meng A  2006  Activation and roles of ALK4/ALK7-mediated maternal TGF-β signals in zebrafish embryoBiochemical and Biophysical Research Communications, 345: 694-703.

Lin X, Duan X, Liang Y.Y., Su Y, Wrighton KH, Long J, Hu M, Davis CM, Wang J, Brunicardi FC, Shi Y, Chen YG., Meng A and Feng, X.H.  2006  PPM1A functions as a Smad phosphatase to terminate TGF-β signaling.  Cell, 125:915-928.

Liu W, Rui H, Wang J, Lin S, He Y, Chen M, Li Q, Ye Z, Zhang S, Chan SC, Chen YG, Han J, Lin SC  2006  Axin is a scaffold protein in TGF-β signaling that promotes degradation of Smad7 by Arkadia.  EMBO Journal, 25:1646–1658.



周芳芳,李志东,王蔚蔚,刘润中,洪水根,许华曦,陈晔光#   2005  双杂交系统筛选与AID相互作用蛋白的初步研究厦门大学学报(自然科学版), 44:299-303.

Li ZD, Wang WW, Zhou FF, Gao X, Peng G, Xu H, Chen YG#   2005  Interactions of Stathmin-like 2 protein with the APP intracellular domain Tsinghua Science and Technology, 10:484-488.

王蔚蔚,李志东,刘润中,洪水根,许华曦,陈晔光#   2005   β-淀粉样前体蛋白胞内端与JKTBP2蛋白的相互作用实验生物学报,38:164-170.

Wang J, Xu N, Feng X, Hou N, Zhang J, Cheng X, Chen YG, Zhang Y, Yang X  2005  Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failure.  Circulation Research, 97:821-828.



Zhang LX, Zhou H, Su Y, Sun S, Zhang H, Zhang L, Zhang Y, Ning Y, Chen YG#, Meng AM#  2004  Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of Nodal receptors. Science, 306:114-117. 

Wang Z, Ren L, Zhao XG, Hung T, Meng AM, Wang J#Chen YG#    2004  Inhibition of SARS virus replication by small interfering RNAs in mammalian cellsJournal of Virology, 78:7523-7527.

Chen YG#, Meng AM#.  2004  Negative regulation of TGF-β signaling in development.  Cell Research, 14:441-449.  (Review)



Zhao XG, Han JD, Ning YH, Meng A, Chen YG#  2003  Bioinformatics analysis of putative gene products encoded in SARS-HCoV genome. Tsinghua Science and Technology, 8:389-394. 



Lu Z, Murray JT, Luo W, Li H, Wu X, Xu H, Backer JM,  Chen YG#   2002   Transforming growth factor β activates Smad2 in the absence of receptor endocytosis.  Journal of Biological Chemistry, 277:29363-29368.

Chen YG, Liu HM, Lin SL, Lee JM, Ying SY  2002  Regulaiton of cell proliferation, apoptosis and carcinogenesis by activin Experimental Biology and Medicine, 227:75-87. (Review)



Huse M, Muir TW, Xu L, Chen YG, Kuriyan J, Massague J 2001  The TGF-β receptor acivation process: An inhibitor- to substrate-binding switch.  Molecular Cell, 8:671-682.



Wu G*, Chen YG*, Ozdamar B, Gyuricza C, Chong PA, Wrana JL, Massagué J, Shi Y.  2000  Structural basis of Smad2 recognition by the Smad Anchor for Receptor Activation.  Science287:92-97. (* contributed equally,并列第一) (Research Article)

Massagué J, Chen YG   2000  Controlling TGF-β signalingGenes & Development, 14:627-644. (Review)

Gouedard L, Chen, YG, Thevenet L, Racine C, Borie S, Lamarre I, Josso N, Massague J, di Clemente N 2000  Engagement of bone morphogenetic protein type IB receptor and Smad1 signaling by anti-Mullerian hormone and its type II receptor. Journal of Biological Chemistry, 275:27973-27978.

Xu L, Chen YG, Massagué J.  2000  The nuclear import function of Smad2 is masked by SARA and unmasked by TGF-β-dependent phosphorylation. Nature Cell Biology, 2:559-562.



Onichtchouk D*, Chen YG*, Dosch, R, Gawantka V, Delius H, Massagué J, Nierhs C  1999  Silencing of TGF-β signalling by the pseudoreceptor BAMBI.   Nature, 401:480-485.  (*contributed equally,并列第一)

Chen YG, Massagué J  1999  Smad1 recognition and activation by the ALK1 group of transforming growth factor-β family receptors Journal of Biological Chemistry, 274:3672-3677.

Pasche B, Kolachana P, Nafa K, Satagopan J, Chen YG, Lo RS, Brener D, Yang D, Kirstein L, Oddoux C, Ostrer H, Vineis P, Varesco L, Jhanwar S, Luzzatto L, Massagué J, Offi K.  1999  TβR-I(6A) is a candidate tumor susceptibility alleleCancer Research, 59:5678-5682.

Huse M, Chen YG, Massagué J, Kuriyan J  1999  Crystal structure of the cytoplasmic domain of the type I TGF-β receptor in complex with FKPB12Cell, 96:425-436.



Chen YG. Hata A*, Lo RS, Wotton D, Shi Y, Pavletich NP, Massagué J  1998  Determinants of specificity in TGF-β signal transductionGenes & Development, 12:2144-2152.  

LoRS*,  Chen YG*, Shi Y, Pavletich NP, Massagué J  1998  The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-β receptors.  EMBO Journal, 17:996-1005.  (*contributed equally, 并列第一)



Chen YG, Siddhanta A, Austin CD, Hammond SM, Sung TC, Frohman MA, Morris AJ, Shields D  1997  Phospholipase D stimulates release of nascent secretory vesicles from the trans-Golgi network.  Journal of Cell Biology, 138:495-504.

Chen YG. Liu F, Massagué J  1997  Mechanism of TGF-β receptor inhibition by FKBP12.  EMBO Journal, 16:3866-3876. 


Prior to 1996

Chen YG. Shields D.  1996  ADP-ribosylation factor-1 stimulates formation of nascent secretory vesicles from the trans-Golgi network of endocrine cells.  Journal of Biological Chemistry, 271:5297-5300.

Chen YG. Danoff A, Shields D 1995 The propeptide of Anglerfish preprosomatostatin-I rescues prosomatostatin-II from intracellular degradationJournal of Biological Chemistry,270:18598-18605.

Davis GM, Liu YY, Chen YG 1990 New genus of Triculinae (Prosobranchia: Promatiopsidae) from China: phylogenetic relationshipsProceedings of the Academy of Natural Sciences of Philadelphia, 142:143-165.

陈晔光  1988  大沼螺的生物学研究。水生生物学报, 12 (2): 97-106.

陈晔光  1988  鄱阳湖及其周围水域的淡水螺类。动物学集刊, 6:69-75.